I've crafted about 200k nature and astral runes in a legit way and I can assure you that the pattern one uses to bank will always be the same. Once you find the most efficient way to bank and you did it a thousand times over it's pretty hard to change even if you wanted to. Due to this I don't like the idea of different banking patterns every run. Screwing up the order of your fills can ofcourse always happen, but no one would use more than one way to close the bank.
Misclicking would be a great addition to antiban. I think I accidentally banked a pouch about once every ten trips, but I don't think your banking method allows for this (which is a good thing, I really like your banking pattern). But yeah, an "accidental" Giant-Large fill instead of the usual Large-Giant fill would be good.
Also, turning the screen when running to the altar would be great. There's nothing else to do, so occasionally I'd tilt my screen up and down or started turning the camera, while still keeping it pointed in the general direction of the altar. Other things I do are checking friends list, hovering various skills, although mainly rc.
Every once in a while right click the tribe dude you pass when running to the altar and recovering summoning points at random intervals instead of at a fixed amount would be good additions too I think. Maybe add idling every once in a while for people who want to use it? I can't craft an hour without stopping to check up on a random thought I got.
I really enjoyed your script so far, used it a couple of days ago and it worked like a charm. One thing I noticed is that at times the cursor moves painstakingly slow towards the altar or bank chest. Still, one of the best scripts out there I believe. Here's a proggy: