Yes, I'm able to hit the hotkeys myself and see the actions take place. For instance if I withdraw the essence myself and click my familiar, the bot will activate and will click teleport, make the runes, tele back, enter the bank preset and then get stuck.Do you have the hotkeys set up?
EDIT:
If you alt + tabbed out of RuneMate, turn on keyboard input, click on the game screen, and press alt once to clear the button.
Never alt-tabbed out. Just exited the bot and restarted it to get past the 6 hour thing