That could be it.
I launch runemate.exe as always, wait for the nice window to pop up but it never happens, it's shown running in the task bar, even in the start bar, but I can't get it to graphically show, however! When runemate is running it's like it's there, blocking the view and any interactions I try to do, for instance, I were playing RS when launching it, but once Runemate was up running, I couldn't control RS either, thought it somehow blocked the keyboard/mouse input prior to even logging in to Runemate, but no, I brought the RS client to front and it worked like normal, tried it with an explorer folder as well and it works, but once I front runemate (the invisible client) it refuses to work.
So it's basically there, but invisible, but still blocking input.